Interstate 40 runs 2,555 miles from Barstow, California to Wilmington, North Carolina, replacing much of the original Route 66 across the West and tying together the Mid-South cities of Albuquerque, Amarillo, Oklahoma City, Memphis, Nashville, Knoxville, and the Research Triangle. It is the third-longest US interstate and a major cross-country freight route. Its busiest truck chokepoints sit in Tennessee, where the Nashville interchanges (I-40 at I-440 and at I-65) rank in the top 25 of ATRI's 2024 Top 100 Truck Bottlenecks and two Knoxville interchanges also make the list.

Geographically I-40 climbs across the Mojave from Barstow, threads the Continental Divide near Thoreau, NM (7,275 ft), drops across the Texas Panhandle, crosses the Mississippi River at Memphis, climbs the Cumberland Plateau in Tennessee, passes through the Smoky Mountains foothills near Knoxville, descends the Pigeon River Gorge into North Carolina (one of the most landslide-prone interstate segments in the country), and rolls flat to the Atlantic at Wilmington.

The corridor is one of the most weather-diverse interstates: high-desert summer heat in the Mojave, ice storms in Oklahoma and Arkansas, severe weather in the Mid-South, and Appalachian winter conditions in eastern Tennessee. The Pigeon River Gorge in North Carolina has been closed for months at a time after major landslides, most recently after Hurricane Helene in 2024.

  • Third-longest interstate in the United States
  • Replaced much of historic US Route 66 across the West
  • Crosses eight states: CA, AZ, NM, TX, OK, AR, TN, NC
  • Continental Divide crossing at Campbell Pass near Thoreau, NM, between Gallup and Grants (7,275 ft), is among the highest interstate points (Wikipedia)
  • Pigeon River Gorge (NC) is one of the most landslide-prone interstate segments
  • Concurrent with I-44 across Oklahoma City and I-440/I-240 around Nashville
  • Memphis is FedEx's global superhub and North America's busiest cargo airport (Memphis International Airport)
  • Nashville is the corridor's worst truck bottleneck: I-24/I-40 at I-440 ranks #10 and I-40 at I-65 #23 nationally (ATRI 2024)