Interstate 75 begins at SR 826, the Palmetto Expressway, in the Hialeah and Miami Lakes area north of Miami, and ends at the International Bridge in Sault Ste. Marie, Michigan, which crosses into Ontario. It runs about 1,785 miles through six states. The FHWA route log (routes as designated on December 31, 2025) gives 470.74 miles in Florida, 354.74 in Georgia, 211.28 in Ohio and 395.35 in Michigan. Its Tennessee and Kentucky figures are shorter than the states' own logs: TDOT's mileposts run to about 161 at the Kentucky line, and KYTC's road log ends at milepoint 191.78 on the Ohio River. I-75 shares 8.00 miles with I-85 on the Downtown Connector in Atlanta and 19.70 miles with I-71 in northern Kentucky, and in west Knoxville it runs on I-40 for about 17 miles, from I-40 exit 368 to exit 385.
Trucks pay tolls in three places, and FHWA lists all three as I-75 toll facilities. Alligator Alley, the stretch across the Everglades between US 27 at Andytown and Naples, is all-electronic with one toll each way. Under FDOT rates effective August 3, 2026, a 5-axle truck pays $12.72 with SunPass or $14.04 by Toll-By-Plate. The Mackinac Bridge charges $5.00 per axle, and the International Bridge charges a 5-axle truck US$33.75 from October 1, 2026. The optional express lanes on I-75 in Broward and Miami-Dade counties and in metro Atlanta are closed to tractor-trailers.
In Atlanta, Georgia law (O.C.G.A. 40-6-51) keeps through trucks off I-75 inside the I-285 Perimeter, between exit 238 on the south side and exit 259 on the north. A truck may go inside only for a pickup or delivery, a terminal or repair shop, or the driver's home there. ATRI's 2026 Top 100 Truck Bottlenecks list puts I-75 at I-285 (North) 5th in the country and I-75 at McDonough, Georgia, 10th. Ninth is I-71 at I-75 in Cincinnati, at the Brent Spence Bridge over the Ohio River. Heavy construction on a companion bridge started there in spring 2026, and the new span is due to open in 2031. Kentucky made I-71/75 across the bridge a restricted route for hazardous materials effective July 15, 2013, and northbound hazmat trucks go around on I-275 east.
In Tennessee, I-75 crosses Jellico Mountain in Campbell County between exit 134 (Caryville) and exit 160 (Jellico). Across the line, KYTC's road log shows grades of about 4 to 4.9 percent in Whitley County, 6.0 to 6.1 percent for about a mile in Laurel County (northbound, mileposts 46.9 to 48.0) and Rockcastle County (southbound, mileposts 66.0 to 67.0), and up to 6.3 percent on the hill in Covington just south of the Brent Spence Bridge. In Michigan, the Mackinac Bridge Authority closes its bridge to high-profile vehicles at sustained winds of 50 to 65 mph and to all traffic at 65 mph or more, and falling ice has closed it 44 times since 1995.
- About 1,785 miles: 470.74 in Florida, 354.74 in Georgia, 211.28 in Ohio and 395.35 in Michigan (FHWA route log, routes as designated on December 31, 2025), plus about 161 in Tennessee (TDOT) and 191.78 in Kentucky (KYTC road log)
- Southern end at SR 826 (Palmetto Expressway), exits 1A and 1B, in Hialeah and Miami Lakes. Northern end at the International Bridge in Sault Ste. Marie, MI, past the last exit, 394 (FDOT; MDOT)
- The second-longest north-south Interstate. Only I-95 is longer, at 1,904.61 miles (FHWA route log)
- Trucks pay tolls on Alligator Alley in Florida and at the Mackinac Bridge and the International Bridge in Michigan (FHWA toll facilities table)
- Through trucks may not use I-75 inside the I-285 Perimeter in Atlanta, between exits 238 and 259. Fines run $150 to $1,000 per violation (O.C.G.A. 40-6-51, Georgia DPS)
- Shares 8.00 miles with I-85 on the Atlanta Downtown Connector (exits 242 to 251) and 19.70 miles with I-71 in northern Kentucky (FHWA route log; GDOT). Runs on I-40 for about 17 miles in west Knoxville, from I-40 exit 368 to exit 385 (TDOT)
- Three of the top 10 in ATRI's 2026 Top 100 Truck Bottlenecks are on I-75: Atlanta at I-285 north (5th), I-71 at I-75 in Cincinnati (9th) and McDonough, GA (10th) (ATRI)
- Brent Spence Bridge Corridor: heavy construction began in spring 2026 on a double-deck companion bridge west of the Brent Spence, due to open in 2031, with the approaches substantially complete by 2033. The old bridge will then carry local traffic only (ODOT and KYTC)
- Mackinac Bridge: closed to high-profile vehicles at sustained winds of 50 to 65 mph and to all traffic at 65 mph or more. Trucks keep right with no passing, and the limit is 45 mph, or 20 mph over 30 tons (Mackinac Bridge Authority)