Interstate 55 runs 964 miles from LaPlace, Louisiana — just outside New Orleans — to Chicago, Illinois, shadowing the Mississippi River for much of its length. It is the principal north-south corridor of the central US, tying together New Orleans, Jackson, Memphis, St. Louis, and Chicago. The route replaces much of historic US Route 66 between St. Louis and Chicago.

For freight, I-55 is the spine of the Mississippi River intermodal network. Container traffic from the Port of New Orleans and the Memphis FedEx hub moves on I-55, and the St. Louis-to-Chicago segment carries some of the highest truck volumes in the central US. The route connects to I-40 at Memphis (one of the busiest east-west truck transfers in the country), to I-70 and I-64 at St. Louis, and to I-80 / I-90 / I-94 in Chicago.

Geographically I-55 is mostly flat, crossing the Mississippi delta in Louisiana, the bluffs around Memphis, the rolling Ozark foothills in southeastern Missouri, and the prairie of central Illinois. Weather hazards are dominated by hurricane evacuations from coastal Louisiana, Mississippi River flooding that closes the Bonnet Carré and other low-lying segments, severe weather across the Mid-South, and lake-effect snow at the Chicago terminus.

  • Shadows the Mississippi River from LaPlace, LA to Chicago, IL
  • Crosses six states: LA, MS, TN, AR, MO, IL
  • Replaced much of historic US Route 66 between St. Louis and Chicago
  • Memphis-Arkansas Bridge crossing is a critical Mississippi River chokepoint
  • Designated hurricane evacuation route from coastal Louisiana
  • Concurrent with I-44 / I-70 / I-64 in St. Louis
  • Connects Port of New Orleans to the Chicago intermodal hubs